Health Advisor

Methylene blue (MB), also known as methylthioninium chloride, is a bioactive substance and a blue dye. Methylene blue (MB), as the first fully man-made medicine, has a wide range of clinical applications. Apart from its well-known FDA approved applications in surgical staining, malaria, and methemoglobinemia, the anti-oxidative properties of MB recently brought new attention to this century-old drug. Some researchers believe that it can directly improve cellular and mitochondrial function and decrease the production of proteins linked to Alzheimer’s. It is also being studied for its potential to inhibit monoamine oxidase (MAO), nitric oxide (NO) synthase, and guanylate cyclase [ Rojas, 2013 ,  Tucker, 2017 ]. Mitochondrial Mechanisms During brain aging, mitochondrial dysfunction has been associated with neuronal loss. It has also been observed in many brain diseases, such as Alzheimer’s disease (AD), Parkinson’s disease (PD), and brain injuries [ Nitzan, 2019 ...

What’s NMN? NMN stands for Nicotinamide MonoNucleotide, a molecule naturally occurring in all life forms. At the molecular level, it is a ribo-nucleotide, which is a basic structural unit of the nucleic acid RNA. Structurally, the molecule is composed of a nicotinamide group, a ribose and a phosphate group (Figure 1). NMN is the direct precursor of the essential molecule nicotinamide adenine dinucleotide (NAD+) and is considered a key component to increase NAD+ levels in cells.   What is Nicotinamide Adenine Dinucleotide (NAD+)? NAD+ is an essential coenzyme required for life and cellular functions. Enzymes are catalysts that make biochemical reactions possible. Coenzymes are  ‘helper’ molecules that enzymes need in order to function.  What Does NAD+ Do? NAD+ is the most abundant molecule in the body besides water, and without it, an organism would die. NAD+ is used by many proteins throughout the body, such as the sirtuins, which r...

David Sinclair, Ph.D., A.O. is a Professor in the Department of Genetics and co-Director of the Paul F. Glenn Center for Biology of Aging Research at Harvard Medical School . Dr. David Sinclair’s main research interest is the epigenetics of aging, with a focus on epigenetic reprogramming of aging (e.g. via Yamanaka factors ), NAD+ metabolism and sirtuins, and NAD+ precursors like NR and NMN . You may have come across his published, New York Times best-selling book on aging, “ Lifespan: Why We Age – And Why We Don’t Have To ”, going deeper into those subjects. So what supplements does Professor David Sinclair take to live longer? Keep in mind that to date, Dr. David Sinclair has made a point to not promote or endorse any supplement products. We compiled this list from interviews and books in which Professor David Sinclair mentions supplements he takes. We don’t know if he still takes these supplements, or whether he takes additional supplements ...